PSI-7977 and PSI-938 Trial

[ruba]

Every time I hear about psi-7977 I get butterflies!

[Justme]

Ya know, it is interesting that I emailed them about saving face by offering another alternative to those removed from the Quantum trial due to the PSI 938 debacle and a short time later, they did!  I know it wasnt my email that did it.  But I think some companies really are a little more sensitive to consumers needs and their own public image.  Even if they aren't, they should be.  If the last three years have taught us anything, it is that NO company is invincible.  I feel that all of us consumers need to keep up the pressure with drug companies so they do the right thing by us. 

[ipaqgps]

Ruba,  I do hope you can get it soon! They are putting this drug through so many trials..so many different kinds.  I don't know if this is how it works on all drugs since I never thought much about the whole process.  BUT I did know it takes a lot of time to get the FDA to approve one. 

JustMe.....  Hey I am sure they appreciated your email too.  Maybe not in the same light as mine but that people were watching.  They have to do the right thing to take the product to the end..  If they can get this right it will change treatment to a totally tolerable experience!  That would be so awesome...   What is that hangin says Shimgabliggan... on that interferon and riba! 

 

[ipaqgps]

My friend that was in this cancelled trial has the virus back.  He started with 9.5 million vl and it is almost as high again.  He is feeling OK and was feeling fine before treatment started he just wants to get this dragon out of his body.

They are doing weekly blood work to keep an eye on him.  Scary but he wasn't on the drugs that long..  If all goes well he will be in the 7977 and riba treatment in April..

 

[banarep]

wishing him luck

[ScaredyCat]

me an ruba sitting in a tree
w-a-i-t-i-n-g

perhaps something will work and they'll push it through the FDA.  Lots of peeps interested in these two drugs -not to mention 12 weeks.

Thanks for posting about it!

me so like baby

[ruba]

  How true Scaredy.   I've learned to wait patiently  playing  this game.  Our turn will come.
We are so lucky to be able to do this much easier tx.

[relay]

Good luck to both of you.

 
gabe

[Justme]

Things are moving fast on some of the trials.  I have a few more days dosing (with BMS 79052 and PSI 7977) and I know that there are others who have already finished dosing.  I hear that there is a 95% chance that you are golden if you can hold it for a month following termination of dosing, 99% chance if you go 3 months. 
The FDA requires 6 months before you are declared cured.  I hear they are screening for the extension of the BMS/PSI 7977 trial for GT 1s who have failed the triple and for some naives (recruiting 60 of each I think at the same sites for the original study NCT 01359644)  I don't know about others but I expect they will be starting more trials soon. 
I also read somewhere posted by Gilead Science that they expect to get FDA approval in 2015. 
That is only three more years!  I don't believe they are dumping PSI 938.  I think they are researching it some more as they are other drugs which they were administering at too high a dose apparently?
They probably moved it ahead too fast because they wanted to pair PSI 7977 with a drug from the same company.  Now GS will probably pair 7977 with a GS drug. 

[ipaqgps]

I think both drugs are good......Just not good together. 

JustMe that is great that your almost done.  I am so excited for you!  You are making history! Wow....what a difference in treatment to not have to take the SOC drugs...

It has been over a year now since I finished tx and still feeling better as time goes by. That interferon just knocked me..

Oh and my stocks are OK..I just don't have any in GS.... So they are cashed out and the money is in the account waiting for me to do something with it..  Whatever I doubled my money, which wasn't much, but to make money in the stock market these days I consider it a huge success....

[Justme]

I am glad you are feeling better Rene.  I just got kicked off another forum suddenly and I believe it is because I was promoting
this PSI 7977 medication and attempting to redirect people to consider trials with it.  I also strongly opposed the flagrantly biased position of the moderators of the forum.  Can you believe that the moderator closed a thread
because it was a discussion of the long term side effects of interferon?  If you know what you are getting into and/or have no other choice, then, of course you take the drug just like you would
radiation for cancer because you want to stay alive.  But a lot of people are duped into treating when they don't have to and then end up with awful side effects that are long lasting.  Anyway, I am pretty infuriated right now because I lost 75 journal entries which were a record of my entire treatment.
Anyway, I guess this a vent of sorts.  I have 5 more days of dosing and then after the first month's PCR I will pretty much be able to tell if I will hold the response (at least that is what I hear).   Study coordinator said if I can hold it for a month I am pretty much "golden".  So, after that I will get back to my regular
activity.  I guess it is a good thing I was kicked off that forum because I have spent too much time sitting on my a** throughout this treatment.

[Justme]

Actually it looks like I was kicked off because I had a journal entry that said RIP helpful thread on long lasting
effects of interferon.  I indicated that it was helpful.  It was certainly controversial.  The mods on that forum do not
like to be criticized and do take a position.  If you go against the position you are expelled. 

[ipaqgps]

Wow touchy group they were.  Sorry you lost your entries but it doesn't sound like a healthy place to be. 

You know it all depends on how sice you are what you chose to do.  I remember when I first came to this site.  It was suggested that if I could hold off and not do treatment that might be the better thing to do because of the new drugs.  Success rate might have been the primary factor then....  I couldn't wait and I found the study so it worked out even though I took the SOC's.   Even if I would have known a year later I could participate in one with them it probably wouldn't have mattered.  It was time to kick this thing with something. 

One day in the near future the ones of us that did it the "hard" way will tell our stories to the new peeps..  Kind of like when I was a kid I had to walk to school 5 miles each way uphill in the snow...  LOL Except we did take a rough hike! 

Just a few more days.....it is going to be a great day when you get your first month past you and it is still UND.....Happy Dance Time!

[Justme]

I should clarify something I said.  It was pointed out to me PM.  The one month post treatment PCR may not pick up the virins left because they still may be flying under the radar so the next test is usually 3 months and that will tell if the virus is gone or not. 

[banarep]

Actually it looks like I was kicked off because I had a journal entry that said RIP helpful thread on long lasting
effects of interferon.  I indicated that it was helpful.  It was certainly controversial.  The mods on that forum do not
like to be criticized and do take a position.  If you go against the position you are expelled.

does not sound like a nice site at all.  may I ask the name?  a PM would be fine.

and glad you are here with us.